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Re: question for chemist about seroquel » linkadge

Posted by chemist on May 12, 2004, at 12:52:43

In reply to question for chemist about seroquel, posted by linkadge on May 11, 2004, at 18:49:06

> On rxlist.com it says that seroquel is an antagonist at 5-ht1a. Is it an antagonist at the 5-ht1a presynaptic autoreceptor, or the post synaptic receptor.
>
> If it is an antagoist at the postsynaptic receptor then wouldn't this be bad for depression?
>
> Linkadge

...and also antagonist of 5-HT_{2}, D_{1}, D_{2}, adrenergic receptors alpha_{1} and alpha_{2}, and histaminergic H_{1}.....as to whether the receptor in question is before the synapse or on the other side of the endplate of the axon, it would appear that the issue here is broad-specturm antagonism and not interuppting a nerve impulse, hence pre- or post- ought not to matter......if anyone else can shed light on my (admittedly) questionable answer, please do....all the best, chemist


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