Posted by chemist on May 10, 2004, at 22:16:32
In reply to Re: neurontin and the Ca or Mg thing...., posted by jlbl2l on May 10, 2004, at 20:03:48
hey there, gimme until tommorow or later tonight to get my ducks in a row. initial guess: rapid desensitization of calcium-channels, add-on benzodiazapine, reduce calcium inhibition by glutamate release, stimulate GABA via the preexisting route...but let me confirm/deny/adjust...as for the chelates: these will not be antacids with the base being - especially for the non-formally charged amino acids at physiological pH - the deprotonated form of, e.g., glycine....more later, let me look into this and see what i can find.....all the best, chemist
> thanks for the help again...
>
> but theorize here w/me for a sec...
>
> in my original post, i stated that i had been on neurontin previously, and within weeks i had to raise the dose to get the same effect, and then i got no effect at all at *any* dose. What would this indicate? This happened in a matter of 2 weeks. Calcium channels? Do you think there is an inborn feedback mechnizsm in the channels/brain that is stopping the neurontin's effect? This seems very odd only after a few weeks use.
>
> Also, theorize, how could we subvert this? As i stated in my original post, a few months later, i restarted neurontin, and to my surprise, it worked full force again! YET again within 2 weeks time the same pattern as above followed.
>
> Could there be a build up or calcium ? desensitation of receptors (rapid) and then (rapid) resensitation? It just doesn't add up...
>
> Your a chemist my friend, brain storm some theories for me. I'll give you more info since your a benzo expert. After the neurontin had stopped working, i took klonopin. Once i felt the klonopin kick in, i took the neurontin, just to see what would happen. Keep in mind they both work through totally different mechinisms. But guess what? I got the neurontin feeling back, while it wasnt full force, it wasn't "nothing". This brings into effect the gaba rasining abilty of neruontin and klonopin. Now how could, if neurontin is completly gained tolerance in me (or i feel so) could i have felt anything from it, when combining it with klonopin? It just doesn't make sense.
>
> I'm still willing to try calcium chelate route, but what dose? Very high correct? and then I would have to wait 2 hours or so before taking neurontin ? or are calcium chelate's not considered antacids as well?
>
> jlbl2l
poster:chemist
thread:345062
URL: http://www.dr-bob.org/babble/20040510/msgs/345591.html