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Re: Does Sonata/Amb.act on the same GABA as Klonopin? » florence

Posted by chemist on May 10, 2004, at 13:06:40

In reply to Does Sonata/Amb.act on the same GABA as Klonopin?, posted by florence on May 9, 2004, at 22:55:29

> I am chronically fatigued. Provigil used to help and I discovered by accident that when I took Sonata (Zaleplom) I noticed SIGNIFICANT lifting of my mood.. I noticed on a Chronic Fatigue Site that Klonopin is one of the top drugs used for Chronic Fatigue Syndrome. The dose is 2 or more 0.5 mg tablets at night. "Paradoxically, very small doses (usually one quarter to one half of a tablet) in the morning and mid-afternoon improves cognitive function and energy. If the daytime dose is low enough you'll experience greater clarity and think better. If the daytime dose is too high, you'll be drowsy."... Anyhow, I am in a really bad state. So, I have got to call my pdoc this week..Should I bother requesting Klonopin? I already take Xanax to counteract the anxiety(?) (crying, irritable, drop in mood) that occurs when the Provigil wears off each day. I apologize if this doesn't make alot of sense. I can't think very clearly. I want to know if Sonata or Ambien even, act on GABA the same way.. I have had no luck with lamictal, trileptal, zyprexa, neurontin, etc. There is a theory that NMDA is more activated than GABA in patients with "actual" Chronic Fatigue Syndrome. Thanks for any help.

hello there....sonata and ambien bind to sub-units of the GABA receptor in a different fashion than do benzodiazepines, although the resultant anxiolytic effects (or hyponotic/sedative) are from the same mode of action with the receptor....i recall a very short action for sonata, and it being used (mostly) for people who have trouble falling asleep; ambien lasts longer, and is used when one has trouble falling asleep and staying asleep. the site-selectivity in the GABA type A receptor probably accounts for some non-benzodiazepine characteristics of these drugs, e.g., preservation of duration spent in a couple(?) of sleep stages....hope this helps a bit, and all the best, chemist


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