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Re: ATTN: Chemist! Your opinion on MAOI + Remeron... Sad Panda

Posted by chemist on May 4, 2004, at 16:57:02

In reply to Re: ATTN: Chemist! Your opinion on MAOI + Remeron... chemist, posted by Sad Panda on May 4, 2004, at 15:59:08

> > > > > Chemist!
> > > > >
> > > > > Do you think Remeron and Nardil is a safe combo...
> > > > >
> > > > >
> > > > > BTW, I checked you out through google...man, your profile is impressive!
> > > > >
> > > > > Take Care,
> > > > > Ace
> > > >
> > > > thanks for the compliment, ace....i can only quote from the PDR Drug Guide for Mental Health Professionals: ``Serious, sometimes fatal, reactions have been known to occur when drugs such as Remeron are taken in combination with other drugs known as MAO inhibitors,, including the antidepressants Nardil and Parnate.'' enough said. remerol floods synapses with norepinephrine and serotonin, which are contraindicated with MAOIs.....all the best, and thanks for the pat on the back! chemist
> > > >
> > > >
> > >
> > > Hi Chemist,
> > >
> > > AFAIK, Remeron isn't a SRI or NRI, so you should be able to take it with nearly anything.
> > >
> > > Cheers,
> > > Panda.
> > >
> > >
> > >
> > hi panda....as you correctly state, remeron is not a serotonin or norepinephrine reuptake inhibitor. however, by antagonizing the alpha_{2} adrenergic receptor which subsequently leads to increaded serotonin and norepinephrine levels. the fact that it is NOT an SRI or NRI and that it stimulates higher levels of S and N makes it even more dangerous if used with an MAOI.....all the best, chemist
> >
> >
>
> Hi Chemist,
>
> I thought that effect was more theoretical rather than actual & it has never been proven that Remeron increase serotonin or norepinephrine levels.
>
> Cheers,
> Panda.
>
>
>
see Mol. Psychiatry 8:994-1007 (2003) for experimental confirmation that mirtazapine is an antagonist of 5-HT_{3};

Neuropsychobiology 47:31-36 (2003) for experimental confirmation of mirtazapine reduces hypercorisolism and is an antagonist of 5-HT_{2}, 5-HT_{3} and H_{1};

Am. Fam. Physician 67:547-554 (2003) for a review, in the abstract it is stated ``Mirtazapine...is unique in its action -- stimulating the release of norepinephrine and serontonin.'' (i assume they do cite the appropriate refs therein);

Int. Clin. Psychopharmacol. 17:319-322 (2002) for mirtazapine antagonizing alpha2-adrenergic receptors with result of increased norepinephrine and serotonin activity; ``Histamine H2 receptors are also antagonized, as are postsynaptic serotonin 5-HT2 and 5-HT3 receptors, leading to serotonergic activity primarily via 5-HT1A receptors.''

Hum. Psychopharmacol. 17 Supp 1:S17-22 (2002) for ``Cell firing is reduced by SSRIs in the short-term, but is increased by mirtazapine, probably due to its actions on both NA (via alpha(2) antagonism) and 5-HT (via alpha(1)-stimulation by NA).''

all the best, chemist


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