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Re: Nardil anticholinergic vs. adrenergic SEs » Questionmark

Posted by Sad Panda on April 30, 2004, at 10:39:08

In reply to Nardil anticholinergic vs. adrenergic SEs, posted by Questionmark on April 30, 2004, at 3:54:28

> 1) DO MAOIs (esp. Nardil) have anticholinergic properties?

Given that MAOI's raise levels of all neurotransmitters, I would say they are procholinergic & proadrenergic to some degree. :)

> 2) Are there adrenergic effects that can be subjectively similar or identical to anticholinergic effects?

I don't think so, but I'd actually have to look it up. I know what agonism & antagonism does at some receptors, the ones that differentiate non-MAOI drugs. ie: Alpha 1 NE blockade causes orthostatic hypotention & reflex tachcardia, but what does agonism do? Ach-Muscarinic blockade causes memory problems, dry mouth, increased eye ball pressure & constipation, but what does agonism do?, cause drooling & diarrohea? :)

SSRI's raise serotonin which causes extra agonism at all 5-HT receptors. 5-HT1 receptor agonism is believed to be what causes an AD effect. 5-HT2A agonism causes excess REM sleep & vivid dreams, antagonism increases deep sleep & may be anxolytic. 5-HT2C is tied to sexual function, agonism causes anorgasmia, antagonism reverses it & is said to be anxiolytic by some. 5-HT3 agonism causes nausea.

I will have to look up what others do, anyone got a good site?

Cheers,
Panda.


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