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Re: Question for chemist on benzos (experts) + MORE. jlbl2l

Posted by chemist on April 22, 2004, at 23:10:31

In reply to Re: Question for chemist on benzos (experts) + MORE., posted by jlbl2l on April 22, 2004, at 21:42:28

> thank you very much. very helpful. i would like your thoughts more on pregabalin (overall) as its approval in europe is expected very shortly (next month) and in oct probably in the USA, and what you meant by the ill-fated comment on it. You can relate its effects to neurontin since literature on pregablin may be lacking due to its relative "newness".
>
> also, i do disagree with you on some points specifically, i have read numerous reports on the net that most benzos convert eventually to either oxazepam or nordiazepam-valium covering the most common benzos (mostly for drug screening).

***have you tried www.pubmed.org with keywords benzodiazepine and oxazepam? also, given that oxazepam is an active anxiolytic, why would there be a market at all for any of the other benzos? the active metabolites are different. if oxazepam comes out the back end, so to speak, then fine. but if you look at the literature (everything from tandem MS/GC to HPLC and more), law enforcement focuses on the metabolites i mentioned.*******
>
> The other thing is the neuropeptide-Y. There is lots of literate on its relation to topamax on medline and why it causes weight loss, sleep problems etc etc. I don't quite understand what you meant by your post regarding NPY/topamax (nothing found?)
***have plenty in my files, but only 2 are relevant: first off is Richard et al., Nutrition 16:961-966, 2000, which says no for the interaction. however, a more recent pub says yes (this one for NPY, CRH, galanin, and leptin): Hushum et al., Neuropsychophamacology 28:1292-1299, 2003*********
>
> One last thing, did you mean the student comment (students like me) thing as a complement, as in, challenging you for the good or bad, or am i actually decent on my knowledge at the age of 21? PS. I don't take any meds currently. I'm just a researcher, I'd like to get my ph.d. someday though.
>
> jlbl2l
****compliment. in regards to your other post, i am covered by numerous non-disclosure agreements with private concerns so i regret i cannot get involved.....***** best, chemist


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