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Re: Pindolol and Zoloft » BobS,

Posted by chemist on April 12, 2004, at 21:45:35

In reply to Re: Pindolol and Zoloft » chemist, posted by BobS, on April 12, 2004, at 19:49:22

hi bob....a few things...indeed pindolol is an antagonist of the serotonin 1A receptor subtype, and is indicated for additional therapy to boost serotonin levels. as for zoloft - or any SSRI - the pindolol ought to work by bringing you up-to-speed in a short time. paxil has a very little affinity for muscarinic receptors. this class of receptors is responsible for things like increased sweating, diarrhea, and increased production of mucus. as far as i know, the only difference between zoloft and paxil is that zoloft does not exhibit appreciable binding to muscarinic receptors: otherwise, both SSRIs hit more or less the same receptors in addition to 5-HT_{1A}. your doctor's anti-muscarinic arguement is not borne out by exstensive studies. further, he/she is probably wary of prescribing it in light of the U.K. and recent U.S. warnings for paxil and SSRis, respectively. HMOs/malpractice at work...in summary, pindolol is being used to ``jump start'' the zoloft effects. give it time, and investigate the second-generaton SSRIs such as effexor and serzone, where there is some antagonism of norepinephrine and dopamine receptors....please let me know if any of this helps, chemist

> Chemist,
> Thanks again. Pindolol is used as an augmentation strategy with SSRIs. I believe it is a mild 5HT1a antagonist and does "something" to autoreceptors. Various medline abstracts find efficacy and others don't. In my case, it is supposed to make it easier for me to get onto a therapeutic dose of Zoloft. That is why I wonder what is so special about Zoloft in my doctor's mind. We are in NJ the home of Pfizer, but I am pretty sure he is more interested in medicine and science than Pfizer's stock price. Never-the-less, I am still baffled. You are probably correct, he just had a lot of success with it. BTW, he does not like Paxil, something about anti-muscarinic(sp?) even though Preskorn.com says all those secondary features in SSRIs are meaningless. My pdoc talks alot about the secondary features...
>
> A friend of 40 years was on Xanax for 18 years at a 4 to 6 mg dose for panic and agoraphobia. She switched to Zoloft about a 1 and 1/2 years ago and felt great. It made me feel like I was jumping out of my skin. Go figure.
> Regards,
> BobS.


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