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Re: Concurrent use of 2 Drugs Metabolized by 2d6 Enzym » Ame Sans Vie

Posted by Sad Panda on March 25, 2004, at 10:04:17

In reply to Re: Concurrent use of 2 Drugs Metabolized by 2d6 Enzym, posted by Ame Sans Vie on March 25, 2004, at 9:03:24

> Also, about inhibitors of 2D6 causing reduced efficacy of some drugs, this *does* happen in a few cases. Codeine, hydrocodone, oxycodone, and tramadol, for example, will not be (as) effective when administered with a 2D6-inhibitor. They all rely on this enzyme to convert to their prodrug forms -- morphine, hydromorphone, oxymorphone, and o-desmethyltramadol respectively.
>
>

Wouldn't this just mean that the onset of effects is slower from these drugs?

Cheers,
Panda.



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