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Re: Klonopin half-life

Posted by KXo on March 18, 2004, at 20:36:09

In reply to Re: Klonopin half-life, posted by djmmm on March 18, 2004, at 19:44:50

> > > It can vary from individual rates of metabolism as well as methods used to calculate half lives (according to the package insert from Roche, it's 30 to 60 hours, although studies independent of Roche have shown greater variability, possibly because of methodology variation, or, as it is metabolized by the CYP3A pathway, P450 inducers can effect the plasma levels and excretion rates). The exact half life is less important than the recognition of it's fairly long half life. This allows for once or twice a day use.
> >
> > what!? my doc said it was something like 6 or 8 hour half life... in fact.... i painstakingly found this to be true... at least.. i found if i were socializing 24/7 i would need to take it three times a day
>
> The ACTUAL half life of Klonopin ranges from 18-50 hrs
>
> xanax is 6-12
>
> Valium (parent drug) is 20-100, 36-200 for the active metabolite desmethyldiazepam
>
> ativan is 10-20
>
> The wide variations in half-life are due to several factors including: duration of use, individual metabolism...also, benzodiazepines tend to accumulate in the fatty tissues of your body.

All this variations make me think it is better to take it as needed, as I am doing, not taking it more than 3 times a day.
The problem is that I don't feel stable doing this way.

It seems like the levels of Klonopin in a persons body will be constantly changing. Sometimes it is the clonazepam from the pill, sometimes the clonazepam from the fat and if you take it everyday.. from both! What do you think?

This half-life... if it is 15 hours for a person at a giving day, does it mean it will be reliefing his anxiety for 15 hours??

==KXo


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