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Re: Dosage of Galantamine for non Alzheimer Purpos » rod

Posted by SLS on March 6, 2004, at 9:26:44

In reply to Re: Dosage of Galantamine for non Alzheimer Purpos » SLS, posted by rod on March 6, 2004, at 8:26:37

Dear Roland,

> > How would you describe your illness? Maybe it has a few things in common with mine. What do you feel the amantadine is doing for you? My cocktail is similar to yours. I'm taking Lamictal, imipramine, Zoloft, memantine, and Abilify. If you continue to improve with galantamine, I'll definitely put it on my list of things to try.

> Well, its a mixture of many diagnosis. I have comorbid ADD (I did a computer test and I performed very poor),

My cognition is greatly impaired by this illness. I don't doubt that I would perform poorly on any kind of exam, including ADD. Maybe I should take the same one to see how our scores compare.

> Social Anxiety Disorder (But I would rather say I am just socially withdrawn. I like to be alone most of the time and avoid masses of people. I dont feel comfortable if there are many people around)

I have experienced exactly what you describe here. I even hide when I see people walking outside that might be able to look through the window. I don't want to be seen. I experience anxiety in social situations that involve more than one person. However, I think this is more a manifestation of the depressive disorder than a comorbid condition.

> my current doctor said i have some aspects of the deficit syndrome (but without ever having psychosis or beeing schizophrenic),

My doctor used the exact same terminology to describe me. The deficit syndrome can exist independant of schizophrenia or major depression or can be associated with either.

http://www.biopsychiatry.com/anhedschiz.htm

> maybe ultra rapid cycling with mainly mixed states, and dystymia with recurrent depressive episodes.

Up until lithium was introduced at age 22 (now 44 - ouch), I had been an ultra-rapid cycler. I would be depressed for 8 days followed by 3 days of euthymia followed by 8 days of depression, etc. It was a dramatic and consistent phenomenon. Lithium abolished the cycling, but left me chronically depressed without relent.

> And maybe some kind of subsyndromal epilepsy, because of hypoperfusion. Also the temporal lobe. This might explain my ADD symptoms and why I get worse on SSRIs (Temporal Lobe ADD).

Hmmm. How are these things linked? How does the temporal lobe relate to SSRI-induced exacerbation of your depression? The following drugs made me feel moderately or severely worse:

moclobemide (Manerix, Aurorix)
protriptyline (Vivactil)
bupropion (Wellbutrin)
topiramate (Topamax)
tiagabine (Gabitril)
triiodothyronine (Cytomel)
amoxapine (Asendin)
mirtazepine (Remeron)
idazoxan (investigational)

> But I fact I dont know what is causing what and if things are comorbid or are seperate.

Depression has many faces. It is possible that all of your symptoms represent a presentation of a single depressive illness. When a drug works for me, all of these symptoms vanish at once. My problem is that a robust response only lasts for days or weeks. They poop-out immediately.


- Scott

 

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