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Re: Lack of motivation due to SSRI's

Posted by interject79 on March 5, 2004, at 22:02:07

In reply to Re: Lack of motivation due to SSRI's, posted by Donia on March 3, 2004, at 0:53:34

It probably is okay to take with Lexapro, but the benefits might not be all that great. Fatigue can be a persistent side effect of SSRIs at certain strengths. Lexapro (and Celexa) is known to be sedating as is Paxil. Prozac is often more activating, as is Effexor. Zoloft can be slightly activating. But I've found that 'activating' when referring to an SSRI is a misnomer, unless you become hypomanic or manic.

SSRIs seem to have an antagonistic impact on dopamine (perhaps dopamine receptors) and even acetylcholine--even if it's an indirect one--so it is difficult to rid oneself of the fatigue. Your doctor might have suggestions for augmenting or lowering your dosage. However, IMO SSRIs shouldn't be utilized indefinitely. I believe they work best in acute circumstances, then very gradually and safely tapered.

Best,
interject


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