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Re: Synthroid or Cytomel -what's the diff}}Bill

Posted by noa on February 3, 2004, at 12:09:16

In reply to Re: Synthroid or Cytomel -what's the diff}}Bill, posted by Maxime on February 2, 2004, at 17:23:18

I think the other posters summed it up. I would only add that T4 is the more stable form of the thyroid hormone that the body is able to store. It is the one that is used by the pituitary to gauge how much TSH to send to the Thyroid gland to signal it to produce hormone. When there is a lot of T4 floating around, the need to produce more is low--ie, low TSH.

One of the problems is that when doctors use TSH and T4 as the only measures of whether someone is hypothyroid, they might draw an eroneous conclusion based on low TSH and adequate T4 if the problem lies in the person's difficulty converting the storage form of hormone--T4--to the active form of hormone--T3. So, some people need both T4 and T3 to reverse symptoms of hypothyroidism or to get antidepressants to work better.

BTW--Cytomel (T3), is shorter acting than Synthroid. This means that Cytomel doses might need to be split into two half-doses per day to avoid uneven surges of the hormone,which can possibly lead to heart palpitations, etc.


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