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Re: galantamine

Posted by Chairman_MAO on January 30, 2004, at 21:59:22

In reply to Re: galantamine, posted by SLS on January 30, 2004, at 16:00:48

Choinergics can worsen depression because, on a neurological level, dopamine and acetylcholine (and I think norepinepherine and acetylcholine, too) counterbalance each other (the real picture is way more complex than I will ever understand). On a psychological level, which often makes more sense when talking about drugs that affect the MIND, "if you think too much, you're gonna be depressed", hehe.

I'd imagine this might not be as bad on Nardil because it increases DA activity to some extent. I used galantamine for months, and found that there was quite a discernable line between enhanced cognitive function and outright thought-frenzied depression. The difference was night and day, and seemed to occur if I exceeded 15mg/day.

I doubt there would be an interaction with an MAO inhibitor; I recommend consulting a doctor because of the risk of worsening depression or other disorders (I believe people with BPD, for instance, have a severe drop in mood if challenged with acetylcholinesterase inhibitors)


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