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Re: IfTransdermal Selegiline is approved Sunday...

Posted by bipolarspectrum on January 30, 2004, at 16:44:24

In reply to Re: IfTransdermal Selegiline is approved Sunday... » bipolarspectrum, posted by rod on January 30, 2004, at 16:39:10

Roland,
You are correct.. my going through the skin, the drug bypasses the so-called 'first-pass effect', which is a term used to describe the phenomen whereby a drug must bypass the liver and its metabolic enzymes before entering the bloodstream and reaching its target (assuming its target is not the liver or GI tract)... As oral selegiline is associated with high levels of amphetamine-like compounds due to first pass, administration via skin significantly reduces this and therefore reduces much of the 'side-effects' which are caused by the amphetamine-like compounds, such as jitteryness and insomnia..
As you may tell from my posts, I'm very excited about the potential benefit of transdermal selegiline..


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poster:bipolarspectrum thread:307271
URL: http://www.dr-bob.org/babble/20040127/msgs/307424.html