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Re: Difference between Sulpiride Amisulpride?

Posted by SLS on January 22, 2004, at 18:48:27

In reply to Difference between Sulpiride Amisulpride?, posted by jparsell82 on January 22, 2004, at 18:02:13

> Hi, could someone tell me how Sulpiride & Amisulpride differ? Are they the same thing, very similar? Do they have the same effects on dopamine? Thanks a lot.


Sulpiride and amisulpride are chemically related and very similar clinically. Both have antidepressant properties at low dosages and antipsychotic properties at higher dosages. Amisulpride binds more tightly to dopamine D2 receptors than does sulpiride. Because of this, the dosage range for amisulpride is lower than that of sulpiride.

Which one is better for depression?

I don't know. I don't remember anyone trying both to be able to compare.

One of my doctors prefered using sulpiride. He thinks that amisulpride is more of an antipsychotic. Although there have been a few people reporting success using sulpiride on Psycho-Babble, amisulpride seems to be the more popular drug. Amisulpride is the newer of the two, and is quite a bit more expensive. However, at the low dosage used for depression, 50mg, it is still affordable.

- Scott




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