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Re: Thoughts on the 5h2a receptor » linkadge

Posted by Sad Panda on January 8, 2004, at 7:41:03

In reply to Re: Thoughts on the 5h2a receptor, posted by linkadge on January 8, 2004, at 6:44:54

> Acording to
>
> http://sl.schofield3.home.att.net/medicine/psychiatric_drugs_chart.html
>
> The only tryciclic that has appreciable affinity for blocking the 5-th2a receptor is amitryptaline.
>
> I thought that anafranil was essentially a very sertogenic tryciclic.
>
> Linkadge
>
>

According to
http://www.psychotropical.com/notes/628.html

-------------------------------------------------
5-HT2A receptors

Studies using sleep EEGs on new drugs like nefazodone and mirtazapine suggest that 5-HT2A blockade produces an improvement in sleep patterns that is clinically useful. Many antidepressant drugs have such properties, data as below. Low numbers means high potency, ie bigger effect.
Many neuroleptic drugs, both old and new, are also potent 5-HT2A blockers.

SSRIs nil sig except
fluoxetine 280

Trimipramine 15
Amitriptyline 18
Clomipramine 23
Doxepin 27
Trazodone 25
Nefazodone 26
mirtazapine ~30
Nortriptyline 41

Imipramine 150
desipramine 350
lofepramine 200


Dr Ken Gillman MRC Psych

PsychoTropical Research

Email me any relevant comments - kgillman@psychotropical.com

-------------------------------------------------

My understanding is that anafranil has the most effect on 5-HT when compared to other tricyclics too, but it also affects a lot of other receptors, ie: clomipramine, imipramine, amitriptyline & doxepin all have very similar NE reuptake inhibiting abilites.



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URL: http://www.dr-bob.org/babble/20040105/msgs/297986.html