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Re: Lamictal vs. Depakote

Posted by SLS on November 8, 2003, at 16:07:26

In reply to Re: Lamictal vs. Depakote » amy_oz, posted by Dinah on November 7, 2003, at 10:18:00

Here's an excerpt from the Lamictal monograph posted at rxlist:

http://www.rxlist.com/cgi/generic/lamotrigine_cp.htm


"Valproate decreases the apparent clearance of lamotrigine (i.e., more than doubles the elimination half-life of lamotrigine), whether given with or without EIAEDs. Accordingly, if lamotrigine is to be administered to a patient receiving valproate, lamotrigine must be given at a reduced dosage, no more than half the dose used in patients not receiving valproate (see DOSAGE AND ADMINISTRATION and PRECAUTIONS: Drug Interactions)."

 

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