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Bupropion for SSRI sexual dysfunction

Posted by KXo on November 7, 2003, at 10:25:49

In reply to Re: Solving SSRIs sexual dysfunction, posted by edw on November 6, 2003, at 15:30:43

Why??? I thought it should work at least in half of the people.
KXo

Sustained-release bupropion for selective serotonin reuptake inhibitor-induced sexual dysfunction: a randomized, double-blind, placebo-controlled, parallel-group study.

Masand PS, Ashton AK, Gupta S, Frank B.

Department of Psychiatry, State University of New York Upstate Medical University, Syracuse, NY 13210, USA. givenss@upstate.edu

OBJECTIVE: The authors compared low-dose sustained-release bupropion with placebo for sexual dysfunction induced by selective serotonin reuptake inhibitors (SSRIs). METHOD: Thirty adults who had received SSRIs for at least 6 weeks, who were euthymic, and who had sexual dysfunction as determined by a total score greater than 19 out of a possible 30 on the Arizona Sexual Experience Scale were randomly assigned to receive either 150 mg/day of sustained-release bupropion or placebo at 6:00 p.m. for 3 weeks. RESULTS: There were no significant differences between the sustained-release bupropion and placebo groups as measured by change in Arizona Sexual Experiences Scale or Hamilton Depression Rating Scale scores or side effects. CONCLUSIONS: Future studies should compare higher doses of bupropion for treating sexual dysfunction and should include a greater number of subjects.

Publication Types:
Clinical Trial
Randomized Controlled Trial

PMID: 11329407 [PubMed - indexed for MEDLINE]


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poster:KXo thread:277044
URL: http://www.dr-bob.org/babble/20031105/msgs/277449.html