Posted by Jasmine Neroli on October 28, 2003, at 0:29:30
In reply to Re: Remeron- an inhibitor of serotonin?, posted by john1022 on October 25, 2003, at 11:36:45
Remeron's first and most potent action is as an Histamine 1 antagonist. Then it next (at higher dosage) is a Norepinephrine Alpha 2 antagonist, and finally it it's an antagonist of the Serotonin receptors 5-ht2a, 5-ht2c and 5-ht3. It doesn't affect 5-ht2b...which apparently is the one that causes sexual side effects. So it's Serotonin activity doesn't come into to play until higher doses. I've read that as being both 37.5 and 45mg. I'm not sure how accurate they (researchers) can really be. Basically at a very low dose (7.5mg) all you get is the Histamine blocker, giving the sedation.
Hope that helps.
poster:Jasmine Neroli
thread:272826
URL: http://www.dr-bob.org/babble/20031025/msgs/274129.html