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Re: Need NMDA Antagonist info - here btnd

Posted by jodeye on October 19, 2003, at 10:15:13

In reply to Re: Need NMDA Antagonist info - here jodeye, posted by btnd on October 19, 2003, at 1:57:32

> Once again I'll bring some of andrewB's information plus my comments.
> Amphetamine tolerance is caused by excess Ca++ influx through the NMDA receptor gated calcium channels on the outer membranes of the dopamine cells bodies in the ventral tegental area, one of two areas in the brain with concentrations of dopamine producing neurons.

Does this mean that amphetamine tolerance really means DA tolerance, not NE tolerance?

Does *dopamine cell* mean a neuron that produces DA, or a neuron that has DA receptors alongside the NMDA receptors?

If *dopamine cell* means a neuron that produces DA, does this mean that excess calcium influx is causing excess dopamine production/release at the other end and therefore causing tolerance?




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