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Re: Need NMDA Antagonist info ratgrrl

Posted by jodeye on October 19, 2003, at 9:38:37

In reply to Re: Need NMDA Antagonist info, posted by ratgrrl on October 18, 2003, at 22:55:50

> I'm actually starting to study a bit about NMDA in another context, and probably can't answer your question, but I am curious. Could you clarify a bit? Which receptors are NE and DA receptors? Are they receptors on the actual NMDA ion channel?


NE receptor = norepinephrine receptor located on the cell membrane of a neuronal dendrite.

DA receptor = dopamine receptor located on the cell membrane of a neuronal dendrite.

My question is: Is stimulant tolerance the result of NE receptor downregulation, or DA receptor downregulation, or both, or neither, or something entirely different.

Do NMDA antagonists prevent stimulant tolerance by reducing NE and/or DA downregulation?

Can NMDA antagonists prevent downregulation of NE and/or DA receptors that is caused by molecules other than stimulants?

Thanks.


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URL: http://www.dr-bob.org/babble/20031015/msgs/270782.html