Posted by jodeye on October 19, 2003, at 9:38:37
In reply to Re: Need NMDA Antagonist info, posted by ratgrrl on October 18, 2003, at 22:55:50
> I'm actually starting to study a bit about NMDA in another context, and probably can't answer your question, but I am curious. Could you clarify a bit? Which receptors are NE and DA receptors? Are they receptors on the actual NMDA ion channel?
NE receptor = norepinephrine receptor located on the cell membrane of a neuronal dendrite.DA receptor = dopamine receptor located on the cell membrane of a neuronal dendrite.
My question is: Is stimulant tolerance the result of NE receptor downregulation, or DA receptor downregulation, or both, or neither, or something entirely different.
Do NMDA antagonists prevent stimulant tolerance by reducing NE and/or DA downregulation?
Can NMDA antagonists prevent downregulation of NE and/or DA receptors that is caused by molecules other than stimulants?
Thanks.
poster:jodeye
thread:270690
URL: http://www.dr-bob.org/babble/20031015/msgs/270782.html