Psycho-Babble Medication | about biological treatments | Framed
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Re: Zoloft affect dopamine at all?

Posted by Caleb462 on October 15, 2003, at 23:54:45

In reply to Zoloft affect dopamine at all?, posted by superRitchie on October 15, 2003, at 21:49:07

> Ive hurd many stories that zoloft affects dopamine, and many stories it hasnt. does zoloft really affect dopamine at high doses, or is that a bunch of bullcrap(ive hurd its more potent than even wellbutrin at high doses) I'm starting zoloft so, does any experinced people know how it affects you? Thanks Ritchie

Zoloft is a weak inhibitor of dopamine reuptake. In the usual dosing range (50-200 mg), I doubt there is any noticeable dopaminergic effect. However, if one were to push the dose higher (say 300-400 mg), I bet some signifigant DA reuptake inhibition would begin to take place. This is just a guess though.




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