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The correct way to LOWER cortisol

Posted by davpet on October 14, 2003, at 12:26:58

I know many of you have tried to lower cortisol , but have been unsuccessful . The reason you cannot lower cortisol directly is because cortisol is needed to de-activate the HPA axis , by means of the negative feedback loop , and as such the HPA axis will continue to produce more cortisol .

You could lower cortisol by taking cortisol inhibiting drugs (ketoconazole etc) and then taking synthetic cortisol (hydrocortisone) to match the the NORMAL diurnal cortisol rhythm, thus tricking your HPA axis into regulating itself as it should.

Refer to this article for more info :

Disclaimer : This theory is exactly that THEORETICAL so do not attempt this unless under the supervision of an experienced medical doctor.

Ketoconazole is liver toxic in the doses required for corisol synthesis inhibition +400mg . It is thus advised that you have your liver values tested regularly if attempting this procedure . If elevated trying switching to another cortisol inhibiting drug metyrapone ; aminoglutethimide etc.




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