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Re: Effexor side effects - heart palpitations darthwribar

Posted by Salty_Dog on October 6, 2003, at 17:06:37

In reply to Re: Effexor side effects - heart palpitations, posted by darthwribar on October 6, 2003, at 8:16:40

I have found a statement concerning arrhythmia and angina pectoris (chest pain) in < 1% of the trial victims. I also found a direct statement concerning withdrawl:

Abrupt Discontinuation of EFEXOR-XR: Discontinuation symptoms have been assessed both in patients with depression and in those with anxiety. Abrupt discontinuation, dose reduction, or tapering of venlafaxine at various doses has been found to be associated with the appearance of new symptoms, the frequency of which increased with increased dose level and with longer duration of treatment. Symptoms reported included agitation, anxiety, confusion, dry mouth, fatigue, paresthesias, vertigo, hypomania, nausea, vomiting, dizziness, headache, diarrhoea, sleep disturbance, insomnia, sweating and nervousness. Where such symptoms occurred, they were usually self-limiting, but in a few patients lasted for several weeks. Discontinuation effects are well known to occur with antidepressants. There is also a report of a withdrawal syndrome, confirmed by two challenges in a 32 year old woman who had received venlafaxine 300 mg daily for 8 months. It is therefore recommended that the dosage of EFEXOR-XR be tapered gradually and the patient monitored. The period required for discontinuation may depend on the dose, duration of therapy and the individual patient (See DOSAGE AND ADMINISTRATION).




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