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Re: Choline idea is BS?

Posted by linkadge on October 3, 2003, at 8:42:57

In reply to Re: Choline idea is BS?, posted by Joe Schmoe on October 2, 2003, at 20:30:32

The cholinergic theory is just a theory.

The discontinuation happens for this reason.

When you boost serotonin levels, there is a corresponding drop in dopamine levels (through activation of 5ht2 receptors) Anyhow, over time the dopamine receptors increase their sensitivity in order to compensate for less dopamine.

Anyhow when you discontinue, process happens in reverse. Dopamine levles resume to predrug status, which is only intesified by supersensitive receptors. This is why you can actually have a high shortly after discontinuing.

Anyhow, low serotonin and high dopamine causes the symptoms of discontinuation such as depression, anger, rage, panic, crying, feeling hot all of a sudden, feeling so utterly wronged.


Boosting cholinergic transmission can intesify that by increasing dopaminergic transmission.
Not to mention that choline itself can perpetuate depression and is generally an ill-advised nutrient for people suffering from depression.


The only way to get off an SSRI sucessfully is to slowly let the system adjust to less serotonin.
To avoid withdrawl symptoms you must taper the drug over the course of weeks to months.

Other ways are to try an support the serotogenic system in other ways - perhaps more taperable ways - such as supplements like magnesium, folic acid, 5htp, exercise.

The problem is that when you discontinue an SSRI you get biologically angry, and you project that anger onto the drug that you took. If your withdrawl is severe, you need to resume some of the initial dose. And taper more slowly.

Withdrawl sucks, I just got off of celexa about 3 months ago, and am now doing fine, but these are the things that helped me.

Oh - and I forgot to mention blueberry extract, boosts neurogenesis which can help you cope while the system adjusts.


Linkadge


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URL: http://www.dr-bob.org/babble/20030928/msgs/265168.html