Posted by craig getty on September 27, 2003, at 16:55:05
In reply to Re: MAOI and Ecstacy-- nooo, posted by Questionmark on September 23, 2003, at 21:11:59
I agree with you. I was the person who originally posted the question about MAOIs and MDMA. Here is what I have observed since: I have seen people on maois *safely* do up to 1/2 a hit of x. Twho have done more have had reperucussions, - serious hypertensive reactions. Keep in mind that I don't know what the maoi dosage of these people is - it could be a small dose, plus how often do you know what the dosage of the x is?
Meth & Coke are DEADLY. One of my friends on an MAOI had safely done "a line or two" in the past. But, if you've done coke, you know the problem is that it's hard to stick to "a line or two." He partied too much one night and ended up in the hosipital.
Now, back to x. Unless you actually made it yourself, how the hell would you know what's in it - it could very well be meth. So, you might as well just stay away from all of the above if you're on an MAOI.
I stick to coffee, which is supposed to be bad, but is fine for me. I will also drink a few beers now and then, but if it goes more than 3-4, I end up feeling awful before the end of the night. And, oh yeah, and occassinal toke or two shouldn't hurt you.
> > So MDMA in combination with an MAOi is supposed to be dangerous? What do you think about the information here: http://www.mdma.net/depsave.htm
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> Listen, i'm not personally very conservative when it comes to mixing drugs, but doing ecstacy when on an MAOI is just freaking *dangerous*. Extremely dangerous. In the study from the abtract you provided, they just gave rats deprenyl 30 minutes before the MDMA. So 1., the degree of MAO inhibition probably could not have been as high as someone who has been on an MAOI for weeks or longer. And secondly, deprenyl is mostly just an inhibitor of MAO-B, so it does not cause much increase in serotonin activity-- and none if in small doses (i'm not really sure whether 2mg/kg is a large dose or not, but still).
> For someone on an MAOI-- especially Nardil or Parnate-- to do MDMA/ecstacy, i believe there would be some risk of a hypertensive crisis, and there would be a seriously extreme risk of developing bad serotonin syndrome-- both of which can be fatal and cause brain damage.
> Also, in regard to deprenyl with MDMA and brain damage, i'm not sure but it seems like lilJim was right about what he said too: "still sounds to me like the maoi decreases some bad things from the x 'treatment' of the rats ... only to contribute to some really bad things in that last sentence there"
poster:craig getty
thread:228754
URL: http://www.dr-bob.org/babble/20030923/msgs/263779.html