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Re: Maoi's diff. effect on Serotonin than SSRI's?

Posted by Caleb462 on September 18, 2003, at 22:15:27

In reply to Re: Maoi's diff. effect on Serotonin than SSRI's? » matthhhh, posted by Ame Sans Vie on September 18, 2003, at 21:13:13

> Nardil is typically sedating; Parnate is more amphetamine-like, and some people (though this is very rare) actually develop addictions to the speedy effects of Parnate.
>
> As for their mechanisms of action on serotonin itself, I don't believe there's any difference worth noting... they both inhibit MAO-A, the enzyme which breaks down excess serotonin and noradrenaline in your brain... so they both actually raise levels of serotonin. SSRIs don't; they just sort of put your serotonin system into overdrive. Nardil has more of a GABA effect though (supposedly),


Why do you say supposedly? It has been proven that taking Nardil increases levels of GABA found in the brain.

Personally, I found Nardil fairly sedating the first couple weeks, but it abruptly went away... I take 60 mg/daily, and if I take two of the 15 mg pills at night, it actually gives me insomnia.


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