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Re: Klonopin excellent so far.... but a question » Veagus

Posted by Ame Sans Vie on September 17, 2003, at 21:27:08

In reply to Re: Klonopin excellent so far.... but a question, posted by Veagus on September 16, 2003, at 19:56:51

I'd suggest getting your doctor comfortable with raising the dose to whatever it takes for *you* to feel comfortable. Don't worry about tolerance -- it doesn't happen. You'll become tolerant to any sedative effects you may have, but anti-anxiety effects will always remain. And that pretty much answers your concern about side effects as well -- it's the *side effects* you grow tolerant to, *not* the therapeutic effects.

Aa for GABA to increase effects of benzos, I'd bet it's a placebo effect. Picamilon (GABA bonded to niacinamide, capable of crossing the BBB) and GABOB (gamma-amino-beta-oxybate -- sort of a cross between GABA and GHB) have a definite effect on benzodiazepine potency though. So if your doctor doesn't want to increase your dose and you feel it isn't adequate, you can "naturally" increase its effectiveness with one of these. Inderal (propranolol) also potentiates clonazepam and might even help with that chest tension you mentioned, since it's a blood-pressure med. Finally, cimetidine (Tagamet) taken about 15-20 minutes before your Klonopin dose will increase its effects by about 25%. Tagamet increases Xanax's effects by about 50%, and doubles the effect of Halcion. Finally, Serzone also increases most benzodiazepines' effects and has a mild anxiolytic/antidepressant effect of its own.


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poster:Ame Sans Vie thread:260535
URL: http://www.dr-bob.org/babble/20030917/msgs/261174.html