Posted by linkadge on September 4, 2003, at 12:59:09
In reply to Re: anti-depressants given to those not depressed, posted by irishcatholic on September 4, 2003, at 12:16:39
Depending on the personality type, I believe that they can change the mood of certain indevituals.
Persons who report not being depressed, but tend to be very shy, or introverted, seem to report improvements on this medication, also, people who tend to get very easily angered, can be helped by the medication.
But then again, these symptoms might be a subtype of certain depressive symptoms.
Some studies report that nondepressed peoples personalities change slightly (a little more easy going) when on antidepresants, but when asked wheather the change was worth the side effects, the people said 'not a chance'. I will look for these studies.
More neurotransmitters does not necesarily equade to better mood. As we are starting to find out the common mechanism of these drugs could possibly be to increase BDNF expression.
One study showed that effexor only improved BDNF expression up to a certain dose. Increasing it further actually decreased BDNF expression. So there really is a 'normal' level of these chemicals.
Just like with me, I have tried more celexa, but it doesn't really do much, just more side effects.
Another thing to remember is glutamate toxicity. Too much brain activity can make you manic, and in turn can dammage the brain via glutamate neurotoxicity. IE if the nerve cell doesn't get time to rest then it destroys itself. So, trying to increase the workings of a well working machiene might be asking for troubble.
Linkadge
poster:linkadge
thread:256878
URL: http://www.dr-bob.org/babble/20030902/msgs/256934.html