Posted by CamW. on September 3, 2003, at 1:13:39
In reply to Re: new Paxil alternative » CamW., posted by Nohope on August 29, 2003, at 3:59:22
Nohope - If you look at the three-dimensional configurations of many psychotropics in vivo, they resemble common antihistamines (eg. promethazine). It is just the side groups (-R) that make all the difference.
The traditional antipsychotics (eg. chlorpromazine [Largactil™], fluphenazine - [Modecate™], etc.), the tricyclic antidepressants (TCAs eg. imipramine - [Tofranil™], amitriptyline [Elavil™], etc.), olanzapine [Zyprexa™], clozapine (Clozaril™) and some other of the newer agents (can't remember which ones) have a modified promethazine shape.
I read about this in a really good autobiography by Jean Thuillier, "Ten Years That Changed The Face Of Mental Illness" (1981; English translation, 1999). It's the history of psychotropics by someone who was in the middle of the hunt for new "neuroleptics".
So, is reboxetine a TCA in a fancy dress? Probably! - Cam
poster:CamW.
thread:255207
URL: http://www.dr-bob.org/babble/20030902/msgs/256540.html