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Re: Histamine and Hypersomniac Depression/ADD?

Posted by Larry Hoover on August 11, 2003, at 4:54:10

In reply to Histamine and Hypersomniac Depression/ADD?, posted by DSCH on August 11, 2003, at 3:59:53

> In tracking down information on future drugs aimed at ADD/ADHD, I came across Perceptin, which was being persued by Gliatech until it seems trouble with class-action litigation and the FDA over their post-surgical adhesion control gel ADCON-L sank the company.
>
> Perceptin, "GT-2331", is a selective H3 receptor antagonist. (For a peak at the molecule, go here... http://www.albmolecular.com/features/tekreps/vol03/no25/ and scroll down a bit).
>
> Bring up histamine, and I immediately have a lot of things to say about it, having gone through extensive allergy shot therapy as a kid. I commonly took the OTC anti-histamine Chlortrimeton which is chlorpheniramine, an H1 antagonist. I have felt seriously awful the few times I have taken Benedryl, which is diphenhydramine and another H1 antagonist. Well, my allergy attacks tapered off with time, though I still have them on occasion usually late at night starting with diarrhea before the bronchial constriction and nasal congestion kick in (food allergy?).

Probably.

>More mucking about with Google scared up a number of sites proclaming "Allergic Toxema", "Allergic Tension Fatigue Syndrome", and (shudder) "Chronic Fatigue Immune Dysfunction Syndrome".

I know it's hard to make the distinction, but there's no way to know if histaminic activity is the cause or the consequence of these syndromes, or if an unseen "third party" is the root problem.

> Could all this histamine-related activity from allergy attacks, therapy, and medication from when I was young resulted in damage or imbalance that is now reflected with symptoms that lately crop up as hypersomniac depression/ADD?

My opinion is that I strongly doubt it. More likely, it is merely evidence that you've had a problem for a long time.

> Is it possible I need more synaptic histamine rather than dopamine, norepinepherine, or serotonin?

Every drug you mentioned in this thread is an antagonist, a substance that negates the effect of histamine. You'd need less, not more. However, I think that's a simplistic explanation, in any case (just like the serotonin imbalance explanation for depression).

> If so, how do I go about getting it?
>
> Your thoughts, please!

The simplest things you can try are the B3-family supplements NADH and niacinamide. The former is implicated in central histamine destruction, while the latter inhibits the release of histamine peripherally. I think that excess histamine reactivity is also related to a deficit in methylation (so-called one-carbon metabolism), so in the longer term, supplementation with methyl donors (B-12 and betaine), along with the other B's (B-complex), and the key minerals zinc and selenium, would be helpful.

Lar

 

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poster:Larry Hoover thread:249973
URL: http://www.dr-bob.org/babble/20030807/msgs/249980.html