Posted by Larry Hoover on August 4, 2003, at 7:31:04
In reply to Re: stimulants: tyrosine, phenylalanine, dexedrine, posted by andys on August 2, 2003, at 17:33:35
> Lar,
> To answer your questions:
> I take the acetylated tyrosine, because it’s supposed to be more bioavailable.Acetylation certainly changes the activity of e.g. choline, but I hadn't heard of any benefit from acetylation of tyrosine. I'll look into it.
> Is there an issue in taking tyrosine and phenylalanine not at the same time, so they don’t compete, crossing the blood-brain barrier? What’s your recommendation on when to take them?
I think they're largely interchangeable, but there's no point in taking them at the same time.
> Your mineral question: I’m taking 8 mg. zinc, and 50 mcg. Selenium.
You might want to increase both of those by as much as a factor of four.
> I checked out TMG. My concern is that it is converted to SAMe, and in the past, SAM-e triggers hypomanic anxiety (like almost all serotonergic AD’s do to me). Do you think that a smallish dose (maybe 500 mg.) should be taken, to keep homocystine levels down, without risking the full effect of supplemental SAMe?
You'll know if you're over-stimulated by TMG, but the dose at which that occurs is very different for different people. You have to try it, and pay attention to what happens.
When you take exogenous SAMe (i.e. from outside the body), you bypass all your body's regulatory processes. You can easily exceed the normal physiological concentration of SAMe this way, and SAMe may be found in places where it isn't normally present. If you promote the formation of endogenous SAMe (i.e. from inside the body), your natural control systems are still in place, making sure there isn't going to be too much SAMe formed, and it's in highest concentration where it's supposed to be.
> (The reason I’m so focused on catecholemines is that they give energy without triggering hypomania, whereas serotonergic substances, including SAMe and St. John’s Wart, rarely give energy, but always trigger hypomania.) (Dexedrine has never triggered hypomania, much to my pdocs amazement. It can actually balance out anxiety).
> Thanks,
> AndySounds a bit like the ADHD paradox. And, it's an excellent example of the need to try things to see what they do. Even your pdoc wouldn't have predicted your response to dexedrine, right?
Ame sans vie posted a link to an e-book that has some information you may find useful. The dose recommendations are conservative, in my humble opinion, but I would interpret that to be because the author is not ill. He's not treating an adverse situation. He's otherwise well.
There's a decent discussion of methyl donors (e.g. TMG), and a chapter on energy boosters.
Lar
poster:Larry Hoover
thread:246486
URL: http://www.dr-bob.org/babble/20030802/msgs/247962.html