Posted by john Henry on July 31, 2003, at 11:26:55
In reply to Re: REMERON rocks! » matthhhh, posted by Squiggles on July 31, 2003, at 10:35:09
I have heard remeron classified as a NaSSAs for norepinephrine and serotonin specific(not reuptake inhibitor like SSRI'S) anti depressant.but it easier to classify it as a serotonin(5-ht2a and 5ht2c) and norepinephrine(a-2)receptor antagonists
Basically it is a blocker at receptor sites.When you block certain serotonin receptors you get certain effects.Here is what happens when you block these sites:
Histamine-1 receptor:Sedation
5ht2a:anti-depressant effect,increased rem sleep and an anti-anxiety effect
Alpha-2 NE receptor:anti-depressant effect,arousal and increased libido
Alpha-1 NE receptor:hypotension,sedation
5ht2c:anti anxiety effect,increased appetite
5ht3c:anti-nauseant effect
Remeron binds to histamine 1st,that is why there is so much sedation at lower doses.Its weird because the higher the dose the more it binds to Alpha-2 NE which is resposible for arousal and libido.Hence the arousal cancels the sedation at higher doses.It binds to 5ht2c which is why you tend to see weight gain.I take Remeron and it is the best sleep I ever get.It has a long half life so for me groginess is a problem.I only use it at 15 mgs.I don't think Remeron is good for dysthmic depressives as the tiredness can lead to irritability and agitation.In theory Remeron + an SSRI or WELLBUTRIN is a power combo,hitting RECEPTORS everywhere.Personally I love Remeron And the first few doses feel like you are going under general anesthesia,but its very pleasant.You will either love it or hate it.
I'm just a layman, so it would be
> wise to look at Dr. Ivan Goldberg's site -
> he is very good. I would take a guess though,
> that Remeron is good for you, depending
> on your type of depression, if you have
> anxiety and insomnia, and this drug like
> many, is very dose-dependent and has
> some paradoxical aspects to the dose (i.e.
> the higher the dose the less you sleep).
>
> It is not an SSRI - it is a NSAD - i think.
>
> Squiggles
>
poster:john Henry
thread:246977
URL: http://www.dr-bob.org/babble/20030728/msgs/247018.html