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Augmenting only works if there's already benefit?

Posted by midwest38 on July 27, 2003, at 16:57:57

My young, freshly-minted pdoc said that if I didn't get any improvement at all after my current 5-6 week trial of Wellbutrin 300 mg there would be no point in augmenting the Wellbutrin with any other drugs. He said that augmentation only works to improve an already existing -- but weak -- positive response from the first drug.

Does anybody have any contrary experience? I thought that augmenting drug X with drug Y often produced a good response when neither X or Y worked at all on its own.

In the last 16 years, I've been on a variety of meds for depression, including combinations, and unilateral ECT, all with no success. I want to try several new, "experimental" combinations, but I don't think this pdoc is going to go along.

Any info appreciated.


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poster:midwest38 thread:245905
URL: http://www.dr-bob.org/babble/20030723/msgs/245905.html