Posted by Larry Hoover on July 27, 2003, at 9:42:39
In reply to Larry Hoover, Re: Pfeiffer, posted by McPac on July 27, 2003, at 0:34:43
> NADH is used to destroy histamine in the brain.
> >>>>>>>>>>>>>>>I'm just totally at a loss why Pfeiffer wouldn't have me taking something like NADH then....destroying histamine is their main goal with me!
That's their theory. Whether it's really a problem for you (as a root cause of your symptoms) is not proven, nor is it provable.
> Then, it's not working, is it?
> >>>>>>> Nope! I may very well be getting some other health benefits but my histamine level is certainly not coming down...quite the contrary!
For any treatment I've ever heard of, there will be individuals who fail to respond as predicted. That's why it's an axiom in science that statistics cannot be applied to individuals; statistics represent patterns, and there is no pattern for a single person. After seven months, you've conducted a reasonable trial of their advice, IMHO.
> I cannot conceive of a reason why a B-complex formulation would cause you any harm, notwhithstanding all of Pfeiffer's advice.
> >>>>>>>>>>>I DID see another web site saying absolutely NO folic acid if you have a high histamine level which you are trying to lower.
I've seen a number of sites with the same advice, but they all seem to be based on a single primary source. It's merely repetition of a theme.
Folate is indeed an essential component of histamine synthesis, from the amino acid histidine. However, folate also promotes the creation of other things from histidine, and also plays a role in the destruction of histamine. The balance of these factors will be different in every person. The argument that folate must be avoided to block histamine is a simplification of an exceedingly complex process. You cannot know the relative rate of the individual processes in a single person. It's like looking at a snapshot of the cars tearing around a racetrack. You can't tell from a photo which car is the fastest one.
> TMG will enhance your natural formation of SAMe, via methionine.
> >>>>>>>>>>> I started taking SAM-e recently...is it ok to take SAM-e everyday (or is this not a good idea? i.e., will your body stop making it on its own (or something to that effect?)
I have no idea, but it's reasonable that there may be a feedback inhibition of SAMe synthesis if there's a lot of it floating around.
> I'm just suggesting that your meds may be part of the problem, despite your focus on the nutrients.
> Lithium totally messed with my energy, focus, and ambition. Remeron messed me up in a lot of ways, too.
> >>>>>>>>>The extreme lethargy and tiredness began RIGHT AFTER starting Pfeiffer's supplement plan....the lithium I've taken for 20 years....the Remeron isn't new either....again, it started RIGHT AFTER starting Pfeiffer's plan...my body has gotten more used to the supps but I'm still more lethargic and tired than I was prior to Pfeiffer.
That happens to some people, and for reasons that I've never seen adequately explained.
All I can suggest is that you try varying the supplements you take. For example, drop the inositol for a week, and see if you rebound a bit. Drop the zinc, in similar test. Drop all the B's for a week. That sort of thing.
Or, add in the "forbidden" supps, one at a time, and see if they do anything.
> My advice is free, but that may be all it's worth.
> >>>>>>>>>>It's highly valued by me!
I appreciate that. The reason I raised the issue at all is that you are paying Pfeiffer for advice that isn't working. All I can offer you is another form of advice. It may or may not be of any value to you, either.
> I don't know of a reason why you couldn't take SJW with Remeron, as you can safely combine Remeron with tricyclics and SSRIs.
> >>>>>>>>>> "Oh Happy Day".......I've always wanted to try SJW but I've been on those damned ssri's for eons! I'll look into SJW + Remeron (Remeron does effect serotonin, though I don't believe as much as the ssri's...that's why I thought Rem. might still not be allowed to be combined w/ SJW.....but if I can take the combo, I likely WILL! OK, one more thought now---can SAM-e and SJW be taken together? THANK YOU as always Hoovermeister!!!!
Combining SAMe with SJW (and, presumably, while you're still on Remeron) would require careful monitoring. It can be done. It's a dose issue.
The neat thing about SJW (in my opinion) is that it has many different modes of action, but none of those actions are intense. What I mean is, none of those effects arise from major changes in brain chemistry/function. It's more like, "A little bit here, and a little bit there." Also, SJW clears rapidly from the body, so if adverse effects do arise, withdrawal occurs quickly.
Still, when you get into combinations, predictablility of the effects is drastically reduced. If you decide to try adding in SJW, just make sure that you are familiar with the early signs of serotonin syndrome, in case it becomes an issue for you, and your unique metabolism.