Posted by Larry Hoover on July 26, 2003, at 9:29:22
In reply to Re: Larry Hoover, Re: Pfeiffer » Larry Hoover, posted by samplemethod on July 26, 2003, at 5:40:36
> Lar doesn't niacinamide get converted to niacin eventually so then this thing you say about them having opposite effects is a bit of i dunno.
I'll answer that with a yes, but....
Niacin and niacinamide are similar enough as to share many properties, but different enough to have unique activities, too. There will be conversion of niacinamide to niacin (nicotinic acid), but that will be slow enough to be (most likely) unnoticeable.
"Nicotinamide inhibits polymorphonuclear cell (PMN) and eosinophil chemotaxis and blocks IgE-mediated histamine release and mast cell degranulation."
> If I have small amounts of niacin I dont get the flush. But If i have a large amount I do.
There's a threshold for the effect to be perceptible. That threshold not only differs between individuals, but moreover, will change with time for a particular individual. I am of the understanding that you can develop a tolerance (i.e. lose the flush effect) with long-term niacin supplementation.
> I know ron hill takes niacin with his NADH TMG combo, whereas you take niacinamide with your NADH TMG combo. You both say the niacin or niacinamide in question reduces your irritability.
As I mentioned earlier, most of the effects of these two substances will be similar. In some particular situations, it is the differences that are important.
> I am unsure about it all...got any hard facts about the opposite effects of niacinamide and niacin? I personally believe I have had bad effects from 500mg niacinamide... I guess you could say it benzos me out.. and I dont like that feeling.
Niacinamide, but not niacin, binds quite effectively to the GABA receptor, and thereby increases the sensitivity of that receptor. Again, dose responsiveness is an individual trait.
>I am trying to get to the bottom of it.
I can't find the reference for the central nervous system effect of NADH on histamine.....