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Re: Very Interesting! What is Kinase C?

Posted by linkadge on July 26, 2003, at 1:15:35

In reply to Very Interesting! What is Kinase C? (nm) » linkadge, posted by River1924 on July 26, 2003, at 0:23:57

Im not exactly a scientist, but protein kinase c is a family of kinases that are involved in cellular growth.

Protein kinase C is involved in the regulation of inositol content/distibutionin the brain

Basically high levels of protein kinase C are is one of the only biological markers specific to mania. The effective mood stabalizers all act at by inhibiting protein kinase c. After PKC is inhibited or lowered this leads to chain of events which lower inositol levels in certain areas of the brain.

Recent studies were done using the cancer drug tamoxephen (which happens to be a potent PKC inhibitor). It resulted in rapid reduction of manic symptoms within 7 of 10 of the manic patients involved. Specific PKC inhibitors are being developed but are yet unavailable.

I have been searching for any/all infomation relating different compounds' abilities to inhibit PKC. Some of the major ones I have found are:

Quercetin,
Green Tea,
Vitamin E
Curcumin,

I have expereienced rapid reduction in my manic symptoms following doses of quercetin 500mg, vitamin e produces some of the same effect however not as dramatic.

I describe the sensation as very rapid. It is as if I was a inflatable dummy and somebody pricked me with a pin. I start to deflate and all of a sudden my thoughts become remarkably more clear.

I am personally convinced that PKC pathways are at the core of manic symptoms. I am telling everybody on this board now that sooner or later a lot of people will be relieved when specific PKC inhibiors are released.


Best Of Luck

Linkadge


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