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As dose increases, norepinephrine levels go up! » crazychickuk

Posted by MB on July 16, 2003, at 12:57:11

In reply to Re: how is remeron different to others, posted by crazychickuk on July 16, 2003, at 11:06:39

> how come the grogginess goes as u go up? i am starting on 15mg ?? have to stay on that for 3 weeks till i go bk to doctors? cant handle grogginess for 3 weeks man !!!! and the doctor wouldnt give me anything esle because i dont get on with ssri's, trylics or snri's such as effexor ..

At lower doses, the drug increases serotonin activity, but since it is an antihistamine, it makes you tired. At higher doses, it increases norepinephrine activity. More norepinephrine activity helps wake you up and counteract the antihistamine sedation.

MB


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