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Re: remeron question den2

Posted by Maximus on July 12, 2003, at 14:04:35

In reply to remeron question, posted by den2 on July 11, 2003, at 22:33:34

>My question is ... dose it only take 7.5 mgs to >block 5ht2 and 5ht3 receptors while not getting >the alpha 2 antagonist effect until 15mgs?

My understanding is that you get thoses blockades via alpha 2 antagonism at all doses. But at lower doses like 7.5 mg or 15 mg the antihistasmine reuptake is more "evident".

To put it simple, you have this modulation of 5-HT neurotransmission (5HT2C and 5HT3) via the blocking on pre- and postsynaptic alpha-2 adrenoceptors.

Good luck!





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