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Re: remeron 7.5 mg

Posted by rod on July 9, 2003, at 19:49:38

In reply to remeron 7.5 mg, posted by den2 on July 9, 2003, at 19:17:55

> I like remeron because of it's 5ht2 and 5ht3 antagonism. Does it take only 7.5 mg to block these receptors and then at 15 mg it starts to block alpha 2 receptors? I'd love some information on this because I can't stand alpha 2 antagonists but The 5ht2 and 5ht3 antagonism is great for me.

Hi den2,

lets have a look at

"Imipramine, Mirtazapine, and Nefazodone: Multiple Targets"

If I read the figure right, there is a 10 fold difference in binding affinity between 5-HT2/3 and alpha-2. I dont think there is really a "point" where the alpha-2 antagonism starts. It's ever existent, but 10 times less "strong" than 5-HT2/3 antagonism.
I would just take a dose, at which you are fine and satisfied with the effect you get from remeron. Whatever this is in mg. But I think you already figured it out for you: 7,5 mg.

good luck





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