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Re: Dissociation/derealization helped by a DA agonist? jaby

Posted by ace on July 3, 2003, at 0:42:59

In reply to Dissociation/derealization helped by a DA agonist?, posted by jaby on July 2, 2003, at 17:05:31

This is very interesting, even more so since I've just started a dopamine antagonist- Zyprexa. I havent actually heard of this hypothesis, but I have heard that derealization and depersonalization symptoms result from excessive stimulation of the 5-HT2 receptor. This is why Lamotrigine is used- often with good results. I must say my experience is consistent with this: when I added Lithium to my Nardil after a while derealization got real bad- Lithium increases serotonin. But with the dopamine thing, I'm exploring it. If Zyprexa doesn't work (for my OCD and only a bit remaing derealization after Nardil knocked it in the head) I will then go on to dopamine agonists- 1. Mirapex, 2. Bromocriptine, and more I will research.

Good luck to you!




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