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My moclobemide pooped out - what to do next?

Posted by david maclean on June 18, 2003, at 7:03:55

Hi guys. I have quite a few questions to ask here about moclobemide pooping out. Please bear with me and if you can answer my queries then I would be really very grateful to you!

I have been taking the Reversible MAOI moclobemide for four to five months. Initially I got to 750 mg a day and I had really very good results with that dose!

But after a month or so that dose "pooped out" and after that I did not get any real benefit from it.

At my request my psychiatrist upped the dose to 900 mg but she was reluctant. Sadly, the 900 mg does not give me any improvement.

What dose can I safely go to with moclobemide? I get no side effects (apart from a rather strange thinning of my semen) so side effects are not going to limit me for now.

I seem to recall hearing that 900 to 1200 mg of moclobemide is a more therapeutic dose than the 600 mg recommended here in the UK by the manufacturers. But 900 mg seems high to my shrink.

One thought strikes me. The benefits I got from moclobemide seemed to me to be very similar to what I imagine a stimulant might do to me. I once read that some of the metabolites which an MAOI decomposes to in the body were amphetamine-like substances. If this is correct then maybe what I really need is a an amphetamine-like stimulant in place of an MAOI. (I suffer from chronic depression - I am dysthmic with a lot of apathy and seem to have what some call "atypical" depression.)

Can a stimulant be used with moclobemide? Should I consider asking my shrink to replace my moclobemide with a stimulant? Any recommendations for which stimulant to request?

Thanks for any answers.


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poster:david maclean thread:234733
URL: http://www.dr-bob.org/babble/20030614/msgs/234733.html