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Re: Parnate pharmacology.

Posted by djmmm on May 23, 2003, at 9:43:01

In reply to Re: Parnate pharmacology., posted by Caleb462 on May 23, 2003, at 6:13:55

> > Thank you all for your responses. Cybercafe said something interesting: "maybe nardil is less stimulating because it leads to an increase in GABA?" i never thought of that. What if it would be just as stimulating as Parnate except for its effects on GABA? No, probably not. Cuz Marplan would be stimulating too. And yeah as someone said Parnate feels much like a typical stimulant.
> > Three of you said that you thought Parnate probably has catecholamine- agonist properties. Now that i think about it, i think that's probably right. But that makes me angry. i'm sick of stimulants. i'm sick of the false hope and confidence they give me. Not to mention the anxiety and appetite suppression. i'm sick of stimulants. i just want an antidepressant, not a euphoriant. Wow, have i changed. Okay enough rambling.
>
> Well, cathecolamine-agonist really isn't the correct term, but I believe Parnate probably does have some psychostimulant properties. It doesn't metabolize into amphetamine or methamphetamine, but it IS a related drug, and thus it can be assumed that it has similiar actions. Not neccesarilly of course, but very possible.

There is still a multitude of information to learn about MAO inhibitors, they are complex drugs because MAO is a complex enzyme, and there are most definitely other amines (trace or otherwise) effected. There is evidence that tranylcypromine binds to reuptake pumps (5-ht, DA and NE). I came across an old study on pubmed which stated that tranylcypromine and phenelzine released norepinephrine from stores, while the MAOIs pargyline and iproniazid did not, and studies of tranylcypromine that stated dopamine release was part of it's pharamacology.

When studying something as broad a monoamine oxidase, it is nearly impossible (at this time) to completely determine the function (and resulting effects) of inhibiting this enzyme (afterall, it's found in the brain, heart and liver)


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poster:djmmm thread:227776
URL: http://www.dr-bob.org/babble/20030520/msgs/228556.html