Posted by paulk on April 16, 2003, at 10:44:45
In reply to Re: update to 100mg, posted by Lexxey on April 16, 2003, at 9:58:08
>I am skeptakle [sp?]when folks say they notice something on 25mg or the other lower doses...none of the research says that did anything to the test group except power of suggestion. All of it says that it needs month OR TWO for maximum benefits and the lower doses during the fist period is just getting you body used to it.
From the Drug monograph:
"A fraction of the population (about 7% of Caucasians and 2% of African Americans) are
poor metabolizers (PMs) of CYP2D6 metabolized drugs. These individuals have reduced activity
in this pathway resulting in 10-fold higher AUCs, 5-fold higher peak plasma concentrations, and
slower elimination (plasma half-life of about 24 hours) of atomoxetine compared with people
with normal activity [extensive metabolizers (EMs)]."
That means that for poor metabolizers it is like taking 5 TIMES as much medicine. Not everyone is the same. our metobolic differences are probably more varied thatn our faces - and we don't all look alike. How do you think you would have fared if your doctor started you out on 300mg/day? That would have been equivelent to a poor metabolizer taking 60mg.
Beign a poor metabalizer has the upside of saving money. The message is not that everyone should take a low dosage, but until you know how well you metabolize the med you should start slowly.