Posted by Questionmark on April 9, 2003, at 0:58:46
In reply to Growth Hormone? Social Anxiety?, posted by utopizen on April 8, 2003, at 19:56:45
> Hey, doesn't GHB (Xyrem) act as a type of growth hormone? If so, would taking Xyrem help social anxiety disorder?
>
> ----------
> A preliminary study of baclofen-induced growth hormone release in generalised social phobia.
> Condren RM, Lucey JV, Thakore JH.
> Neuroscience Department, St Vincent's Hospital, Richmond Road, Fairview, Dublin 3, Ireland.
> OBJECTIVE: The authors sought to examine central GABA(B) receptor responses in patients with generalised social phobia using the growth hormone (GH) response to baclofen. METHOD: Baclofen 20 mg was administered to 15 patients and 15 healthy matched controls and plasma growth hormone was monitored over a 3 h period. RESULTS: The GH response in patients was significantly reduced in comparison to that of controls when calculated as both area under the curve (AUC) and delta (Delta) response. CONCLUSIONS: The results suggest an abnormality of central GABA(B) receptor function in this disorder. Copyright 2002 John Wiley & Sons, Ltd.
> PMID: 12590406 [PubMed - in process]Weird. Why would growth hormone help with social anxiety i wonder?
i believe GHB does not act as a growth hormone, it stimulates production and/or release of growth hormone. i thought it does this by means of elevating dopamine levels (as a rebound effect) though. Is GABA(B) stimulation responsible for the rebound DA then (judging from this abstract)? Or am i just mistaken about the involvement of DA? No, i don't think i am though.
Also, if increased DA activity stimulates more GH production/release, then why do psychostimulants suppress growth (and i believe growth HORMONE activity)??? CONFUSION!!
poster:Questionmark
thread:217551
URL: http://www.dr-bob.org/babble/20030407/msgs/217674.html