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Re: Akathisia » SLS

Posted by medlib on March 14, 2003, at 22:20:19

In reply to Re: Abilify drug reaction?, posted by SLS on March 14, 2003, at 19:44:25

Hi Scott--

Found this on an ER guide while wandering around the web trying to decide whether to risk an Abilify trial.

- drugs provoking acute akathisia include neuroleptic agents, serotonin receptor antagonists, lithium, levodopa, calcium channel blockers and phenothiazine anti-emetics eg. prochlorperazine or metoclopropamide

- the etiology of akathisia is unknown, but a good response to propanolol suggests a hyperactive adrenergic system

- the treatment of acute drug-induced akathisia includes anticholinergic agents (diphenhydramine and benztropine) and propanolol +/- opioids

It goes on to say that anticholinergics aren't helpful for chronic akathisia.

Found the following on a medical mnemonics site; since so many of us are taking or considering taking APs, I thought it might be useful.

Neuroleptic side effects onset
The rule of 4's:
Dystonia: 4 hours-4 days
Akathesia: 4 days-40 days
Extrapyramidal symptoms: 4 days-4 weeks
Tardive dyskinesia: 4 months (greater than)
· Note that tardive is obviously the latest one to happen (tardive=tardy/late).
· Note that the first letters of these four classic symptoms spell "DATE", and this mnemonic is the dates when they occur.

Hope that Abilify proves helpful for you.---medlib


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