Posted by djmmm on March 12, 2003, at 8:37:33
In reply to is ZYPREXA a serotonin agonist or antagonist????, posted by ace on March 12, 2003, at 0:16:35
I believe Zyprexa is primarily an antagonist within the serotonin system, it is an antagonist at the 5ht-2a, 2c, 5ht-6, 5ht-3 receptors. However, antagonism at the 5ht-2a and D2 sites can cause 5ht-1a AGONIST activity.
Several dopamine receptors are effected: D1 through D4, it's a histamie antagonist, and alpha-1 receptor antagonist, as well as an acetylcholine receptor antagonist.. Zyprexa has some effect on benzo receptors, too.
poster:djmmm
thread:208300
URL: http://www.dr-bob.org/babble/20030310/msgs/208367.html