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SSRI poop out in teenager - Need help now!

Posted by Abby7 on February 26, 2003, at 19:03:37

7 mos. ago my 14 yr. old's depression returned & so far, nothing has worked & I don't know what to do! A summary, briefly as possible: Age 11 1/2 was first onset of depression. Rec'd Adderall, then ritalin from pediatrician. Result - rages (never happened before) that went away when stimulants stopped. He was left more profoundly depressed than before. Then 20mg Paxil from same Dr. Result: extreme fatigue, loss of inhibilition, more depression. Finally refr'd to psychiatrist, Paxil reduced to 5mg & 150mg wellbutrin added. Much improved. Feeling the SSRI was not needed, eventually tried discontinuing Paxil (with aid of Prozac for discontinuation symptoms. Depression returned when Prozac was stopped. Maintained on 5mg Prozac & 150 wellbutrin & did very well for 1 yr. Depression returned. Tried raising wellbutrin (no help, also can't tolerate over 175mg); tried raising Prozac to 10mg(apathy, emotional lability,insomnia, still depressed); tried switch to Celexa (odd pattern of increase dose, 4 days nothing, then 3-4 very good days, then depression returns, becoming more sad with each dosage increase - stopped at 15mg); Switched to 25 mg Zoloft while titrating down Celexa. Felt best in mos. but has deteriorated in days since Celexa has ended. Increased Zoloft to 37.5 but so far still depressed (fatigued, isolated, no enjoyment, irritable, serious; normal personality is happy, joking, enthusiastic). Dr. has discussed Effexor (I'm worred about discontinuation probs) or tricyclic (I'm worried about side effects - he's been so sensitive to SSRI side effects). What are we missing? Is there possibly a theraputic synergy when small doses of 2 SSRI's are combined (like the Celexa/Zoloft experience)? Why would he previously respond to SSRI's but not now? Any other ideas? His life is falling apart & I can't seem to help him. Welcome any ideas.




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