Posted by Shawn. T. on February 23, 2003, at 22:47:38
In reply to Question for the med heads, posted by Jackster on February 22, 2003, at 23:37:42
Taking Paxil with amitriptyline doubles the serum level of nortriptyline (a metabolite of amitriptyline). I doubt that it's reasonable to extrapolate that data onto your own situation; your body doesn't have to metabolize amitriptyline, and everyone is obviously different. If you have low P4502D6 (an enzyme that Paxil affects) activity, that could affect the situation as well. Based on the fact that people show on average a doubling of nortriptyline concentrations even while having to metabolize amitriptyline as well, you should have no reason to worry while waiting for your test.