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Re: ANYONE ON SELEGELINE? QUESTIONS...

Posted by SLS on February 16, 2003, at 23:26:08

In reply to Re: ANYONE ON SELEGELINE? QUESTIONS... wingedcat, posted by Craig Allen on February 16, 2003, at 21:04:54

> thanks for all the helpful info. in addition to adderall, i'm on effexor (225 mg per day). anyone know if i can augment the effexor with selegiline? i'm going to drop the adderall. i'm hoping that the selegiline will ease the nasty depression that comes with stopping the adderall. thanks again.

That sounds like a reasonable idea. Why can't you simply taper the dosage of Adderall gradually enough to avoid the fatigue and depression associated with abrupt withdrawal? S-AMe might be worth trying.

Combining an MAOI with any drug that potently inhibits the reuptake of serotonin (5-HT) is generally contraindicated. Such combinations often produce a serious reaction called "serotonin syndrome".

See:

http://www.google.com/search?hl=en&ie=UTF-8&oe=UTF-8&q=%22serotonin+syndrome%22&btnG=Google+Search

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12003730&dopt=Abstract

Theoretically, at dosages lower than 10mg, selegiline does not inhibit the MAO-A enzyme that contributes to serotonin syndrome. Dosages of 2.5 - 7.5mg might be safe, but you should be carefully monitored for signs of a reaction. I did a quick search on Medline. Unfortunately, in those abstracts that addressed the combining of selegiline with serotonin reuptake inhibitors, there was no mention of the dosages used. The abstracts that described the incidence of serotonin syndrome as being rare involved the treatment of Parkinsons Disease, for which the dosages of selegiline used are generally no higher than 10mg.

I don't recall reading any personal accounts of using this drug combination. However, if my doctor were to suggest giving it a try, I don't think I would hesitate as long as the dosage used does not exceed 10mg AND I be provided with a list of the symptoms of serotonin syndrome I should monitor.

I hope there's someone here who has actually tried it to give you better feedback. Please post your progress with selegiline. Good luck.


- Scott

 

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